Ensartinib (X-396): what does it add for patients with ALK-rearranged NSCLC

A New Monitor of Pressure Autoregulation: What Does It Add?

EEG in neurological conditions other than epilepsy: when does it help, what does it add?

Correspondence to: Dr Shelagh Smith, Department of Clinical Neurophysiology, The National Hospital, Queen Square, London WC1N 3BG, UK; shelaghs@epilepsynse. org.uk _________________________ A lthough the electroencephalogram (EEG) is a reliable test to assess cerebral function, its value in diagnosis and evaluation of neurological conditions apart from epilepsy has been largely superceded in re...

Focus on Alectinib and Competitor Compounds for Second-Line Therapy in ALK-Rearranged NSCLC

The management of anaplastic lymphoma kinase rearranged (ALK+) non-small cell lung cancer (NSCLC) exemplifies the potential of a precision medicine approach to cancer care. The ALK inhibitor crizotinib has led to improved outcomes in the first- and second-line setting; however, toxicities, intracranial activity, and acquired resistance necessitated the advent of later generation ALK inhibitors....

Looking for a new panacea in ALK-rearranged NSCLC: may be Ceritinib?

In the past decade, the advent of targeted therapy led to a silent revolution in the war against lung cancer and a significant evolution on the concept of Phase I clinical trials design. Thanks to the specificity of their target, the new drugs have radically changed NSCLC treatment, leading to the development of personalized strategies. The accelerated approval of the first ALK-inhibitor, Crizo...

participation, what does it mean?

participation has been with us since the inception of living in a family. participation developed in the matrix of religion and, two centuries ago, opend up its way in political systems of european countries. it supported the democratic principle of people's determining their own destiny. today, participation is considered a necessity for the total development of not only individuals, but ...